Product Data Sheet
mPEG-Mal (MW 5000)
Catalog No. A86474
mPEG-Mal (MW 5000) is a PEG-derived selective covalent binding agent targeting sulfhydryl groups, facilitating irreversible thioether bond formation under near-neutral conditions. This reagent serves dual roles: as an enzyme modifier, it alters protein secondary structures through interactions such as hydrophobicity and hydrogen bonding, and as a nanoparticle surface modifier, it enhances macrophage phagocytosis by covalently binding to red blood cell surface sulfhydryl groups. mPEG-Mal (MW 5000) increases the apparent molecular weight of modified proteins, bolsters enzyme thermal stability and activity, and enhances nanoparticle targeting in drug delivery. Its applications extend to enzyme engineering in the food industry and oncology research, contributing to improved radiotherapy outcomes by modulating macrophage infiltration and anti-tumor immune responses.
Chemical Information
| Catalog Num | A86474 |
|---|---|
| M. Wt | 5000 (Average) |
| Formula | |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 724722-89-8 |
| Synonyms | mPEG-Maleimide (MW 5000) |
| SMILES | COCCOCCNC(CCN1C(C=CC1=O)=O)=O.[n] |
Biological Activity
| Description | mPEG-Mal (MW 5000) is a PEG-derived selective covalent binding agent targeting sulfhydryl groups, facilitating irreversible thioether bond formation under near-neutral conditions. This reagent serves dual roles: as an enzyme modifier, it alters protein secondary structures through interactions such as hydrophobicity and hydrogen bonding, and as a nanoparticle surface modifier, it enhances macrophage phagocytosis by covalently binding to red blood cell surface sulfhydryl groups. mPEG-Mal (MW 5000) increases the apparent molecular weight of modified proteins, bolsters enzyme thermal stability and activity, and enhances nanoparticle targeting in drug delivery. Its applications extend to enzyme engineering in the food industry and oncology research, contributing to improved radiotherapy outcomes by modulating macrophage infiltration and anti-tumor immune responses. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
