Product Data Sheet
Polyquaternium-1
Catalog No. A86892
Polyquaternium-1 (Polidronium chloride; PQ-1) is an effective ophthalmic preservative with antimicrobial properties, which activates the NF-κB signaling pathway. It acts by targeting bacterial cell membranes, utilizing its polycationic nature to disrupt membrane integrity, inducing potassium ion leakage, and resulting in bacterial cell death. At a concentration of 0.001%, Polyquaternium-1 exhibits low toxicity towards mammalian cells, making it suitable for various formulations including glaucoma eye drops, artificial tears, and contact lens solutions. Its use helps to mitigate the ocular surface toxicity associated with conventional preservatives like benzalkonium chloride.
Chemical Information
| Catalog Num | A86892 |
|---|---|
| M. Wt | 556.99 |
| Formula | C22H48Cl3N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 75345-27-6 |
| Synonyms | Polidronium chloride |
| SMILES | OCC[N+](CCO)(C/C=C/C[N+](C)(C/C=C/C[N+](CCO)(CCO)CCO)C)CCO.[3 Cl-].[n] |
Biological Activity
| Description | Polyquaternium-1 (Polidronium chloride; PQ-1) is an effective ophthalmic preservative with antimicrobial properties, which activates the NF-κB signaling pathway. It acts by targeting bacterial cell membranes, utilizing its polycationic nature to disrupt membrane integrity, inducing potassium ion leakage, and resulting in bacterial cell death. At a concentration of 0.001%, Polyquaternium-1 exhibits low toxicity towards mammalian cells, making it suitable for various formulations including glaucoma eye drops, artificial tears, and contact lens solutions. Its use helps to mitigate the ocular surface toxicity associated with conventional preservatives like benzalkonium chloride. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
