Product Data Sheet

Diphenylacetic acid

Catalog No. A86921

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Diphenylacetic acid is a biochemical reagent primarily known for its role in asymmetric synthesis. It facilitates the kinetic resolution of racemic 2-hydroxy-γ-butyrolactones through asymmetric esterification, utilizing pivalic anhydride and a chiral acyl-transfer catalyst. Additionally, it serves as a catalyst in the synthesis of 2-allyl-3-oxazolin-5-one derivatives via Rh-catalyzed coupling reactions of azlactones with alkynes, followed by aza-Cope rearrangement. Its applications are valuable in organic synthesis and pharmaceutical research.
Chemical Information
Catalog NumA86921
M. Wt212.25
FormulaC14H12O2
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.117-34-0
SynonymsDiphenylmethane-α-carboxylic Acid
SMILESO=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2
Biological Activity
DescriptionDiphenylacetic acid is a biochemical reagent primarily known for its role in asymmetric synthesis. It facilitates the kinetic resolution of racemic 2-hydroxy-γ-butyrolactones through asymmetric esterification, utilizing pivalic anhydride and a chiral acyl-transfer catalyst. Additionally, it serves as a catalyst in the synthesis of 2-allyl-3-oxazolin-5-one derivatives via Rh-catalyzed coupling reactions of azlactones with alkynes, followed by aza-Cope rearrangement. Its applications are valuable in organic synthesis and pharmaceutical research.
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