Product Data Sheet
4-Amino-2-chloropyrimidine
Catalog No. A87792
4-Amino-2-chloropyrimidine is a pyrimidine derivative that acts as a competitive inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with inhibition constants (Ki) of 0.18 μM and 1.324 μM, respectively. This compound effectively occupies the binding pocket of the 4BDS structure. Additionally, 4-Amino-2-chloropyrimidine demonstrates potent inhibitory activity against glutathione S-transferase (GST) with an IC50 value of 0.037 μM and a Ki of 0.047 μM. Its biochemical activity makes it a valuable reagent for research in enzyme inhibition and neurochemical studies.
Chemical Information
| Catalog Num | A87792 |
|---|---|
| M. Wt | 129.55 |
| Formula | C4H4ClN3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 7461-50-9 |
| Synonyms | |
| SMILES | ClC1=NC=CC(N)=N1 |
Biological Activity
| Description | 4-Amino-2-chloropyrimidine is a pyrimidine derivative that acts as a competitive inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with inhibition constants (Ki) of 0.18 μM and 1.324 μM, respectively. This compound effectively occupies the binding pocket of the 4BDS structure. Additionally, 4-Amino-2-chloropyrimidine demonstrates potent inhibitory activity against glutathione S-transferase (GST) with an IC50 value of 0.037 μM and a Ki of 0.047 μM. Its biochemical activity makes it a valuable reagent for research in enzyme inhibition and neurochemical studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
