Product Data Sheet
Alloc-Val-Ala-OH
Catalog No. A87850
Alloc-Val-Ala-OH is a biochemical assay reagent that serves as a versatile building block in the synthesis of Tesirine, a clinical antibody-drug conjugate featuring a pyrrolobenzodiazepine dimer payload. This compound is specifically designed for selective cleavage by Cathepsin B, facilitating targeted therapeutic applications. The stable Alloc group withstands exposure to piperidine and TFA, yet it can be conveniently removed under mild conditions through palladium-catalyzed allyl transfer, making it suitable for various synthetic pathways in biochemical research.
Chemical Information
| Catalog Num | A87850 |
|---|---|
| M. Wt | 272.30 |
| Formula | C12H20N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 330970-70-2 |
| Synonyms | ((Allyloxy)carbonyl)-L-valyl-L-alanine |
| SMILES | OC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O |
Biological Activity
| Description | Alloc-Val-Ala-OH is a biochemical assay reagent that serves as a versatile building block in the synthesis of Tesirine, a clinical antibody-drug conjugate featuring a pyrrolobenzodiazepine dimer payload. This compound is specifically designed for selective cleavage by Cathepsin B, facilitating targeted therapeutic applications. The stable Alloc group withstands exposure to piperidine and TFA, yet it can be conveniently removed under mild conditions through palladium-catalyzed allyl transfer, making it suitable for various synthetic pathways in biochemical research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
