Product Data Sheet
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid
Catalog No. A88092
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid is a potent biochemical assay reagent that serves as a robust covalent linker, featuring a free carboxylic acid and two tosyl groups. The tosyl moieties can be displaced by thiol or amine nucleophiles through Michael addition, allowing for dual reactions. This functionality enables the "stapling" of two reduced cysteine residues within proteins, facilitating the reformation of disulfide bridges. Additionally, the carboxylic acid can participate in the formation of amides or esters, expanding its utility in biochemical research applications.
Chemical Information
| Catalog Num | A88092 |
|---|---|
| M. Wt | 500.58 |
| Formula | C25H24O7S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 124243-00-1 |
| Synonyms | Bis–sulfone Acid |
| SMILES | O=C(C1=CC=C(C=C1)C(O)=O)C(CS(=O)(C2=CC=C(C=C2)C)=O)CS(=O)(C3=CC=C(C=C3)C)=O |
Biological Activity
| Description | 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid is a potent biochemical assay reagent that serves as a robust covalent linker, featuring a free carboxylic acid and two tosyl groups. The tosyl moieties can be displaced by thiol or amine nucleophiles through Michael addition, allowing for dual reactions. This functionality enables the "stapling" of two reduced cysteine residues within proteins, facilitating the reformation of disulfide bridges. Additionally, the carboxylic acid can participate in the formation of amides or esters, expanding its utility in biochemical research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
