Product Data Sheet
ABT-737-d8
Catalog No. A92340
ABT-737-d8 is a deuterium-labeled BH3 mimetic that targets Bcl-2, Bcl-xL, and Bcl-w with EC50 values of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. This reagent disrupts the BCL-2/BAX complex and activates the intrinsic apoptotic pathway in a BAK-dependent, BIM-independent manner. ABT-737-d8 promotes autophagy and is valuable for research in acute myeloid leukemia (AML) and related apoptosis studies.
Chemical Information
| Catalog Num | A92340 |
|---|---|
| M. Wt | 821.48 |
| Formula | C42H37D8ClN6O5S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1217686-68-4 |
| Synonyms | |
| SMILES | ClC(C=C1)=CC=C1C(C=CC=C2)=C2CN3C([2H])([2H])C([2H])([2H])N(C4=CC=C(C=C4)C(NS(=O)(C5=CC([N+]([O-])=O)=C(C=C5)N[C@H](CCN(C)C)CSC6=CC=CC=C6)=O)=O)C([2H])([2H])C3([2H])[2H] |
Biological Activity
| Description | ABT-737-d8 is a deuterium-labeled BH3 mimetic that targets Bcl-2, Bcl-xL, and Bcl-w with EC50 values of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. This reagent disrupts the BCL-2/BAX complex and activates the intrinsic apoptotic pathway in a BAK-dependent, BIM-independent manner. ABT-737-d8 promotes autophagy and is valuable for research in acute myeloid leukemia (AML) and related apoptosis studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
