Product Data Sheet
Bis-sulfone-PEG8-NHS ester
Catalog No. A94185
Bis-sulfone-PEG8-NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms from native disulfides. It facilitates bis-alkylation by conjugating thiols derived from the two cysteine residues of a reduced native disulfide bond, such as those present in interchain disulfide bonds of antibodies. This reaction covalently rebridges disulfide bonds via a three-carbon bridge, preserving protein structure. The hydrophilic PEG spacer enhances solubility in aqueous solutions, making it suitable for various biochemical assays and labeling applications.
Chemical Information
| Catalog Num | A94185 |
|---|---|
| M. Wt | 1021.15 |
| Formula | C48H64N2O18S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2363757-66-6 |
| Synonyms | |
| SMILES | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(C1=CC=C(C(C(CS(=O)(C2=CC=C(C)C=C2)=O)CS(=O)(C3=CC=C(C)C=C3)=O)=O)C=C1)=O)ON4C(CCC4=O)=O |
Biological Activity
| Description | Bis-sulfone-PEG8-NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms from native disulfides. It facilitates bis-alkylation by conjugating thiols derived from the two cysteine residues of a reduced native disulfide bond, such as those present in interchain disulfide bonds of antibodies. This reaction covalently rebridges disulfide bonds via a three-carbon bridge, preserving protein structure. The hydrophilic PEG spacer enhances solubility in aqueous solutions, making it suitable for various biochemical assays and labeling applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
