Product Data Sheet
SM-8849
Catalog No. A95332
SM-8849 is a thiazole derivative characterized by its anti-inflammatory properties. This compound selectively targets and inactivates T cells associated with delayed-type hypersensitivity (DTH) reactions, effectively disrupting the key immunopathological processes implicated in arthritis while sparing humoral immune functions such as antibody synthesis. In a Type II Collagen-induced mouse model of arthritis, SM-8849 demonstrated significant efficacy by relieving clinical symptoms and mitigating bone destruction and joint damage. SM-8849 serves as a valuable reagent for research on autoimmune diseases, particularly rheumatoid arthritis.
Chemical Information
| Catalog Num | A95332 |
|---|---|
| M. Wt | 312.40 |
| Formula | C18H17FN2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 113759-19-6 |
| Synonyms | |
| SMILES | FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=CSC(NC)=N3)=C1 |
Biological Activity
| Description | SM-8849 is a thiazole derivative characterized by its anti-inflammatory properties. This compound selectively targets and inactivates T cells associated with delayed-type hypersensitivity (DTH) reactions, effectively disrupting the key immunopathological processes implicated in arthritis while sparing humoral immune functions such as antibody synthesis. In a Type II Collagen-induced mouse model of arthritis, SM-8849 demonstrated significant efficacy by relieving clinical symptoms and mitigating bone destruction and joint damage. SM-8849 serves as a valuable reagent for research on autoimmune diseases, particularly rheumatoid arthritis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
