Product Data Sheet
(Z)-Onjisaponin B
Catalog No. A95881
(Z)-Onjisaponin B is a drug derivative that primarily targets the inhibition of NF-κB p65. This natural product, derived from Polygala tenuifolia, exhibits significant biological activity by enhancing autophagy and promoting the degradation of mutant α-synuclein and huntingtin. Additionally, (Z)-Onjisaponin B reduces β-amyloid (Aβ) production and mitigates radiation-induced cell apoptosis, while also demonstrating antioxidant and anti-inflammatory properties. Its applications extend to research in neurological diseases and radiation injuries, with the ability of its metabolite, tenuifolin (TF), to penetrate the blood-brain barrier.
Chemical Information
| Catalog Num | A95881 |
|---|---|
| M. Wt | 1573.67 |
| Formula | C75H112O35 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 162681-53-0 |
| Synonyms | (Z)-Senegin III |
| SMILES | OC[C@]12[C@]3([C@@](CC=C1[C@@]4([H])[C@@](CC2)(CCC(C)(C4)C)C(O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)C)OC(/C=C\C6=CC=C(C=C6)OC)=O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O[C@@H]%10O[C@@H]([C@@H]([C@@H]([C@H]%10O)O)O)CO)O)O)O)O)=O)([H])[C@@]%11([C@@]([C@@](C)([C@H]([C@H](C%11)O)O[C@@H]%12O[C@@H]([C@H]([C@@H]([C@H]%12O)O)O)CO)C(O)=O)([H])CC3)C)C |
Biological Activity
| Description | (Z)-Onjisaponin B is a drug derivative that primarily targets the inhibition of NF-κB p65. This natural product, derived from Polygala tenuifolia, exhibits significant biological activity by enhancing autophagy and promoting the degradation of mutant α-synuclein and huntingtin. Additionally, (Z)-Onjisaponin B reduces β-amyloid (Aβ) production and mitigates radiation-induced cell apoptosis, while also demonstrating antioxidant and anti-inflammatory properties. Its applications extend to research in neurological diseases and radiation injuries, with the ability of its metabolite, tenuifolin (TF), to penetrate the blood-brain barrier. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
