Product Data Sheet
(±)5-HEPE
Catalog No. B10914
(±)5-HEPE is a drug isomer produced through the non-enzymatic oxidation of eicosapentaenoic acid (EPA), comprising equal amounts of the 5(S) and 5(R) isomers. The biological activity of (±)5-HEPE is primarily attributed to the 5(S) isomer, which plays a role in various mammalian biological systems. In human and bovine neutrophils, as well as human eosinophils, EPA is metabolized to 5-HEPE, which can further be converted to 5-oxoEPE and LTB5. It is important to note that the 5-series metabolites of EPA exhibit significantly reduced biological effects in comparison to metabolites derived from arachidonic acid.
Chemical Information
| Catalog Num | B10914 |
|---|---|
| M. Wt | 318.45 |
| Formula | C20H30O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 83952-40-3 |
| Synonyms | |
| SMILES | CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(O)CCCC(O)=O |
Biological Activity
| Description | (±)5-HEPE is a drug isomer produced through the non-enzymatic oxidation of eicosapentaenoic acid (EPA), comprising equal amounts of the 5(S) and 5(R) isomers. The biological activity of (±)5-HEPE is primarily attributed to the 5(S) isomer, which plays a role in various mammalian biological systems. In human and bovine neutrophils, as well as human eosinophils, EPA is metabolized to 5-HEPE, which can further be converted to 5-oxoEPE and LTB5. It is important to note that the 5-series metabolites of EPA exhibit significantly reduced biological effects in comparison to metabolites derived from arachidonic acid. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
