Product Data Sheet
Fluoresterol
Catalog No. B10980
Fluoresterol (22-NBD Cholesterol) is a cholesterol-specific fluorescent probe designed to bind selectively to cholesterol transport-related proteins, including ABCA1 and ABCG1. This compound serves as a valuable tool for studying cholesterol metabolism, enabling visualization and quantitative analysis of cholesterol absorption, efflux, intracellular transport dynamics, and reverse cholesterol transport processes. Fluoresterol is particularly useful in research exploring the mechanisms underlying hyperlipidemia, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Common application concentrations range from 0.1 to 10 μM in vitro and doses of 5 to 20 mg/kg for in vivo studies, with excitation and emission wavelengths of 472 nm and 540 nm, respectively.
Chemical Information
| Catalog Num | B10980 |
|---|---|
| M. Wt | 494.63 |
| Formula | C28H38N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 78949-95-8 |
| Synonyms | 22-NBD Cholesterol |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CNC3=CC=C([N+]([O-])=O)C4=NON=C34)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O)CC6)=CC5)C)([H])CC1 |
Biological Activity
| Description | Fluoresterol (22-NBD Cholesterol) is a cholesterol-specific fluorescent probe designed to bind selectively to cholesterol transport-related proteins, including ABCA1 and ABCG1. This compound serves as a valuable tool for studying cholesterol metabolism, enabling visualization and quantitative analysis of cholesterol absorption, efflux, intracellular transport dynamics, and reverse cholesterol transport processes. Fluoresterol is particularly useful in research exploring the mechanisms underlying hyperlipidemia, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Common application concentrations range from 0.1 to 10 μM in vitro and doses of 5 to 20 mg/kg for in vivo studies, with excitation and emission wavelengths of 472 nm and 540 nm, respectively. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
