Product Data Sheet
RO 16-6491 free base
Catalog No. B11274
RO 16-6491 Free Base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), demonstrating high affinity for its binding sites in human frontal cortex mitochondria and platelet membranes. This compound exhibits fast dissociation of bound radioactivity at 20 degrees Celsius, highlighting its dynamic binding properties. Additionally, as a substrate for MAO-B, RO 16-6491 may generate a stable intermediate that contributes to its potent inhibitory effects. This dye functions as an effective radioligand probe for examining the regional distribution of MAO-B in various physiological and pathological contexts.
Chemical Information
| Catalog Num | B11274 |
|---|---|
| M. Wt | 198.65 |
| Formula | C9H11ClN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 87235-61-8 |
| Synonyms | |
| SMILES | C1=C(C=CC(=C1)Cl)C(=O)NCCN |
Biological Activity
| Description | RO 16-6491 Free Base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), demonstrating high affinity for its binding sites in human frontal cortex mitochondria and platelet membranes. This compound exhibits fast dissociation of bound radioactivity at 20 degrees Celsius, highlighting its dynamic binding properties. Additionally, as a substrate for MAO-B, RO 16-6491 may generate a stable intermediate that contributes to its potent inhibitory effects. This dye functions as an effective radioligand probe for examining the regional distribution of MAO-B in various physiological and pathological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
