Product Data Sheet
Vepdegestrant-d5
Catalog No. B13687
Vepdegestrant-d5 (ARV-471-d5) is a deuterium-labeled derivative of Vepdegestrant, designed for stable isotope tracing in biochemical studies. It functions as a PROTAC (proteolysis-targeting chimera) to selectively degrade estrogen receptors, particularly in ER-positive breast cancer cells. By promoting the interaction between the estrogen receptor alpha and an intracellular E3 ligase complex, Vepdegestrant-d5 induces ubiquitylation and subsequent degradation of the receptor via the proteasome pathway. This compound exhibits significant biological activity, achieving a degradation concentration (DC50) of approximately 2 nM in relevant cell lines, making it a valuable tool for breast cancer research.
Chemical Information
| Catalog Num | B13687 |
|---|---|
| M. Wt | 728.93 |
| Formula | C45H44D5N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3025452-07-4 |
| Synonyms | ARV-471-d5 |
| SMILES | O=C1NC([C@@H](N(C2=O)CC3=C2C=CC(N(CC4)CCN4CC(CC5)CCN5C(C=C6)=CC=C6[C@H]7[C@@H](C8=C([2H])C([2H])=C([2H])C([2H])=C8[2H])CCC9=C7C=CC(O)=C9)=C3)CC1)=O |
Biological Activity
| Description | Vepdegestrant-d5 (ARV-471-d5) is a deuterium-labeled derivative of Vepdegestrant, designed for stable isotope tracing in biochemical studies. It functions as a PROTAC (proteolysis-targeting chimera) to selectively degrade estrogen receptors, particularly in ER-positive breast cancer cells. By promoting the interaction between the estrogen receptor alpha and an intracellular E3 ligase complex, Vepdegestrant-d5 induces ubiquitylation and subsequent degradation of the receptor via the proteasome pathway. This compound exhibits significant biological activity, achieving a degradation concentration (DC50) of approximately 2 nM in relevant cell lines, making it a valuable tool for breast cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
