Product Data Sheet
Crizotinib-d9
Catalog No. B15038
Crizotinib-d9 (PF-02341066-d9) is a deuterium-labeled derivative of Crizotinib, designed for use as a stable isotope in chemical research. Crizotinib is an orally bioavailable, ATP-competitive inhibitor targeting ALK and c-Met, exhibiting IC50 values of 20 nM and 8 nM, respectively. It is known to effectively inhibit tyrosine phosphorylation of NPM-ALK and c-Met in cell-based assays, with IC50 values of 24 nM and 11 nM. Additionally, Crizotinib serves as a ROS1 inhibitor and demonstrates significant tumor growth inhibition, making it crucial for oncology research applications.
Chemical Information
| Catalog Num | B15038 |
|---|---|
| M. Wt | 459.39 |
| Formula | C21H13D9Cl2FN5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1523580-59-7 |
| Synonyms | PF-02341066-d9 |
| SMILES | C[C@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=CC(C3=CN(C4([2H])C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])N=C3)=CN=C2N |
Biological Activity
| Description | Crizotinib-d9 (PF-02341066-d9) is a deuterium-labeled derivative of Crizotinib, designed for use as a stable isotope in chemical research. Crizotinib is an orally bioavailable, ATP-competitive inhibitor targeting ALK and c-Met, exhibiting IC50 values of 20 nM and 8 nM, respectively. It is known to effectively inhibit tyrosine phosphorylation of NPM-ALK and c-Met in cell-based assays, with IC50 values of 24 nM and 11 nM. Additionally, Crizotinib serves as a ROS1 inhibitor and demonstrates significant tumor growth inhibition, making it crucial for oncology research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
