Product Data Sheet
Lifitegrast-d6
Catalog No. B15079
Lifitegrast-d6 is a deuterium-labeled variant of Lifitegrast, functioning as a potent integrin antagonist. It specifically interferes with the interaction between intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function-associated antigen 1 (LFA-1), disrupting the T cell-mediated inflammatory response. With an IC50 value of 2.98 nM, Lifitegrast effectively inhibits Jurkat T cell attachment to ICAM-1. This reagent is ideal for studies focused on dry eye disease and related inflammation pathways.
Chemical Information
| Catalog Num | B15079 |
|---|---|
| M. Wt | 621.52 |
| Formula | C29H18D6Cl2N2O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2249814-79-5 |
| Synonyms | SAR 1118-d6; SHP-606-d6 |
| SMILES | ClC1=C2C(CN(CC2)C(C3=CC=C(C=CO4)C4=C3)=O)=CC(Cl)=C1C(N[C@H](C(O)=O)C([2H])([2H])C5=C([2H])C(S(C)(=O)=O)=C([2H])C([2H])=C5[2H])=O |
Biological Activity
| Description | Lifitegrast-d6 is a deuterium-labeled variant of Lifitegrast, functioning as a potent integrin antagonist. It specifically interferes with the interaction between intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function-associated antigen 1 (LFA-1), disrupting the T cell-mediated inflammatory response. With an IC50 value of 2.98 nM, Lifitegrast effectively inhibits Jurkat T cell attachment to ICAM-1. This reagent is ideal for studies focused on dry eye disease and related inflammation pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
