Product Data Sheet
D228
Catalog No. B18375
D228 is an orally active anti-inflammatory agent that targets T and B lymphocytes. It effectively reduces ConA-induced T cell proliferation with an IC50 of 42.85 μM and LPS-induced B cell proliferation with an IC50 of 3.15 μM. D228 demonstrates efficacy in the treatment of inflammatory bowel disease (IBD) by alleviating inflammation in the DSS-induced IBD model, primarily through the downregulation of the MyD88/TRAF6/p38 signaling pathway.
Chemical Information
| Catalog Num | B18375 |
|---|---|
| M. Wt | 484.45 |
| Formula | C22H28O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2676188-98-8 |
| Synonyms | |
| SMILES | CC1=C(C(/C(O1)=C(C)\C)=O)O[C@H]2[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2 |
Biological Activity
| Description | D228 is an orally active anti-inflammatory agent that targets T and B lymphocytes. It effectively reduces ConA-induced T cell proliferation with an IC50 of 42.85 μM and LPS-induced B cell proliferation with an IC50 of 3.15 μM. D228 demonstrates efficacy in the treatment of inflammatory bowel disease (IBD) by alleviating inflammation in the DSS-induced IBD model, primarily through the downregulation of the MyD88/TRAF6/p38 signaling pathway. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
