Product Data Sheet
OB-24 free base
Catalog No. B18745
OB-24 free base is a selective inhibitor of heme oxygenase 1 (HO-1), demonstrating notable potential for targeting advanced prostate cancer. This compound effectively reduces protein carbonylation and diminishes the formation of reactive oxygen species in prostate cancer cells through its specific inhibition of HO-1 activity. In vitro studies reveal that OB-24 significantly impairs cell proliferation, while in vivo experiments show a marked reduction in tumor growth and metastasis to lymph nodes and lungs. Additionally, OB-24 displays enhanced efficacy when used in conjunction with Taxol, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | B18745 |
|---|---|
| M. Wt | 337.21 |
| Formula | C15H17BrN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 940061-39-2 |
| Synonyms | |
| SMILES | BrC1=CC=C(CCC2(CN3C=NC=C3)OCCO2)C=C1 |
Biological Activity
| Description | OB-24 free base is a selective inhibitor of heme oxygenase 1 (HO-1), demonstrating notable potential for targeting advanced prostate cancer. This compound effectively reduces protein carbonylation and diminishes the formation of reactive oxygen species in prostate cancer cells through its specific inhibition of HO-1 activity. In vitro studies reveal that OB-24 significantly impairs cell proliferation, while in vivo experiments show a marked reduction in tumor growth and metastasis to lymph nodes and lungs. Additionally, OB-24 displays enhanced efficacy when used in conjunction with Taxol, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
