Product Data Sheet
Tralopyril
Catalog No. B21282
Tralopyril is a potent ferroptosis inducer that selectively targets the thyroid hormone system and mitochondrial oxidative phosphorylation pathways. It promotes ferroptosis by downregulating key transcription factors such as TRHR, Nkx2.1, and TRα, thereby disrupting amino acid, energy, and lipid metabolism. Despite its primary application as an antifouling insecticide, its significant toxicity to skeletal and reproductive systems, alongside its implications for developmental damage, renders it useful in toxicological studies. Tralopyril's long half-life in vivo and broad tissue distribution highlight potential risks to both aquatic organisms and human health.
Chemical Information
| Catalog Num | B21282 |
|---|---|
| M. Wt | 349.53 |
| Formula | C12H5BrClF3N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 122454-29-9 |
| Synonyms | |
| SMILES | C1=C(C=CC(=C1)Cl)C2=C(C#N)C(=C(C(F)(F)F)N2)Br |
Biological Activity
| Description | Tralopyril is a potent ferroptosis inducer that selectively targets the thyroid hormone system and mitochondrial oxidative phosphorylation pathways. It promotes ferroptosis by downregulating key transcription factors such as TRHR, Nkx2.1, and TRα, thereby disrupting amino acid, energy, and lipid metabolism. Despite its primary application as an antifouling insecticide, its significant toxicity to skeletal and reproductive systems, alongside its implications for developmental damage, renders it useful in toxicological studies. Tralopyril's long half-life in vivo and broad tissue distribution highlight potential risks to both aquatic organisms and human health. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
