Product Data Sheet
Melicopine
Catalog No. B21535
Melicopine is an alkaloid derived from Z. simulans, demonstrating potent antimalarial and anticancer properties. It effectively inhibits both chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. In cancer studies, Melicopine exhibits cytotoxicity against prostate cancer cell lines PC-3M and LNCaP with IC50 values of 47.9 and 37.8 µg/mL, while showing minimal effects on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). This compound is a valuable tool for research in the fields of anticancer therapy and anti-infective strategies.
Chemical Information
| Catalog Num | B21535 |
|---|---|
| M. Wt | 313.30 |
| Formula | C17H15NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 568-01-4 |
| Synonyms | |
| SMILES | O=C1C2=C(N(C)C3=C4OCOC4=C(C(OC)=C13)OC)C=CC=C2 |
Biological Activity
| Description | Melicopine is an alkaloid derived from Z. simulans, demonstrating potent antimalarial and anticancer properties. It effectively inhibits both chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. In cancer studies, Melicopine exhibits cytotoxicity against prostate cancer cell lines PC-3M and LNCaP with IC50 values of 47.9 and 37.8 µg/mL, while showing minimal effects on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). This compound is a valuable tool for research in the fields of anticancer therapy and anti-infective strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
