Product Data Sheet
SU015
Catalog No. B21856
SU015 is an antagonist of the integrins αvβ3 and αvβ5, demonstrating comparable affinity for both targets with enhanced potency and specificity. This compound effectively inhibits αvβ3-mediated cell adhesion to fibrinogen and osteopontin, as well as αvβ5-mediated cell adhesion to vitronectin. Additionally, SU015 exhibits significant inhibitory effects on FGF2-induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) model. Its properties allow for potential applications in tumor metastasis studies, and it features a linker arm suitable for radioisotope conjugation, serving as a target-specific radioreagent when labeled with isotopes such as 90Y or 177Lu.
Chemical Information
| Catalog Num | B21856 |
|---|---|
| M. Wt | 1704.84 |
| Formula | C75H113N23O23 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 250612-06-7 |
| Synonyms | DOTA-RGDfK dimer |
| SMILES | O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCNC([C@H](CCC(NCCCC[C@@H]2NC([C@H](NC([C@@H](NC(CNC([C@@H](NC2=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O)=O)NC(CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O)[C@H]1CC5=CC=CC=C5 |
Biological Activity
| Description | SU015 is an antagonist of the integrins αvβ3 and αvβ5, demonstrating comparable affinity for both targets with enhanced potency and specificity. This compound effectively inhibits αvβ3-mediated cell adhesion to fibrinogen and osteopontin, as well as αvβ5-mediated cell adhesion to vitronectin. Additionally, SU015 exhibits significant inhibitory effects on FGF2-induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) model. Its properties allow for potential applications in tumor metastasis studies, and it features a linker arm suitable for radioisotope conjugation, serving as a target-specific radioreagent when labeled with isotopes such as 90Y or 177Lu. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
