Product Data Sheet
4′-O-Methylglabridin
Catalog No. B22032
4′-O-Methylglabridin is an apoptosis inducer that disrupts the cell cycle and exhibits antioxidant and cytotoxic activities against cancer cells. It has been shown to inhibit a range of cancer cell lines, including liver, breast, and colorectal cancers, by reducing phosphorylated Rb and p21 protein levels, leading to an accumulation of cells in the subG1 and G2/M phases. Furthermore, 4′-O-Methylglabridin triggers caspase-dependent apoptosis through the release of cytochrome C and activation of caspase-9. Its antioxidant properties also include the inhibition of lipid peroxidation and prevention of LDL oxidation. This compound is valuable for research in cancer biology and atherosclerosis.
Chemical Information
| Catalog Num | B22032 |
|---|---|
| M. Wt | 338.40 |
| Formula | C21H22O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 68978-09-6 |
| Synonyms | |
| SMILES | CC1(OC2=C(C=C1)C3=C(C=C2)C[C@H](C4=C(C=C(C=C4)OC)O)CO3)C |
Biological Activity
| Description | 4′-O-Methylglabridin is an apoptosis inducer that disrupts the cell cycle and exhibits antioxidant and cytotoxic activities against cancer cells. It has been shown to inhibit a range of cancer cell lines, including liver, breast, and colorectal cancers, by reducing phosphorylated Rb and p21 protein levels, leading to an accumulation of cells in the subG1 and G2/M phases. Furthermore, 4′-O-Methylglabridin triggers caspase-dependent apoptosis through the release of cytochrome C and activation of caspase-9. Its antioxidant properties also include the inhibition of lipid peroxidation and prevention of LDL oxidation. This compound is valuable for research in cancer biology and atherosclerosis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
