AC220 (Quizartinib)

ON SALE

FLT3 inhibitor

0 Customer Reviews
Catalog No. A10027

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AC220 5mg A10027-5

Regular Price: $50.00

Special Price: $40.00

AC220 10mg A10027-10

Regular Price: $70.00

Special Price: $56.00

AC220 50mg A10027-50

Regular Price: $120.00

Special Price: $96.00

AC220 200mg A10027-200

Regular Price: $350.00

Special Price: $280.00

AC220 (Quizartinib) 10mM * 1mL in DMSO A10027-10mM-D

Regular Price: $126.00

Special Price: $100.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.

AC220 (Quizartinib)

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A10027
Actions Inhibitor
M. Wt 560.7
Formula C29H32N6O4S
Solubility DMSO>112mg/mL Water<1mg/mL Ethanol>4mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 950769-58-1
Synonyms N/A
SMILES code CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
Chemical Name 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea

Biological Activity

Description
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
Targets
FLT3 (ITD) (MV4-11 cells) FLT3 (WT) (RS4;11 cells)
1.1 nM4.2 nM

Solubility

Solubility (25°C) * In vitro DMSO 33.2 mg/mL (59.21 mM)
Water <0.3 mg/mL ( mM)
Ethanol <0.5 mg/mL ( mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Biological Activity

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220, which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor. [1][2]

References on AC220 (Quizartinib)
  • [1] Blood 2009;114: 2984-2992
  • [2] Clin Adv Hematol Oncol. 2010 Jun;;8(6):429-44.
Read More

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Similar product(s)


Keywords:buy AC220 (Quizartinib) | AC220 (Quizartinib) Supplier | purchase AC220 (Quizartinib) | AC220 (Quizartinib) cost | AC220 (Quizartinib) manufacturer | order AC220 (Quizartinib) | AC220 (Quizartinib) distributor | buy 950769-58-1| 950769-58-1 Supplier | purchase 950769-58-1 | 950769-58-1 cost | 950769-58-1 manufacturer | order 950769-58-1 | 950769-58-1 distributor