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AC220 (Quizartinib)


FLT3 inhibitor

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Catalog No. A10027

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AC220 5mg A10027-5

Regular Price: $50.00

Special Price: $40.00

AC220 10mg A10027-10

Regular Price: $70.00

Special Price: $56.00

AC220 50mg A10027-50

Regular Price: $120.00

Special Price: $96.00

AC220 200mg A10027-200

Regular Price: $350.00

Special Price: $280.00

AC220 (Quizartinib) 10mM * 1mL in DMSO A10027-10mM-D

Regular Price: $126.00

Special Price: $100.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.

AC220 (Quizartinib)

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Chemical Information

Catalog Num A10027
Actions Inhibitor
M. Wt 560.7
Formula C29H32N6O4S
Solubility DMSO>112mg/mL Water<1mg/mL Ethanol>4mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 950769-58-1
Synonyms N/A
Chemical Name 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea

Biological Activity

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
FLT3 (ITD) (MV4-11 cells) FLT3 (WT) (RS4;11 cells)
1.1 nM4.2 nM


Solubility (25°C) * In vitro DMSO 33.2 mg/mL (59.21 mM)
Water <0.3 mg/mL ( mM)
Ethanol <0.5 mg/mL ( mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Biological Activity

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220, which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor. [1][2]

References on AC220 (Quizartinib)
  • [1] Blood 2009;114: 2984-2992
  • [2] Clin Adv Hematol Oncol. 2010 Jun;;8(6):429-44.
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