AMG-458

Catalog No.: A11055
c-Met inhibitor
AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
Grouped product items
Product Name Stock
AMG-458 5mg
AMG-458 10mg
AMG-458 50mg
AMG-458 100mg
AMG-458 10mM * 1mL in DMSO
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Biological Activity
Discription AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
Targets
Target Value
Product Information
Catalog Num A11055
Formula C30H29N5O5
Molecular Weight 539.6
CAS Number 913376-83-7
SMILES CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC
Synonyms AMG458, AMG 458
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 18 mg/mL (33.35 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol+citrate vehicle 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.66 mL 185.32 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
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