ALK-IN-1, an analog of AP26113, is an orally-available, potent, and selective inhibitor of ALK with a potency of 0.62 nM against wild-type and activity against a wide range of mutants, including the crizotinib-resistant L1196M line.
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| Description | ALK-IN-1, an analog of AP26113, is an orally-available, potent, and selective inhibitor of ALK with a potency of 0.62 nM against wild-type and activity against a wide range of mutants, including the crizotinib-resistant L1196M line. | |||||
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| Targets |
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| Cell Research |
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| Catalog Num | A11948 |
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| Formula | C26H34ClN6O2P |
| Molecular Weight | 529.01 |
| CAS Number | 1197958-12-5 |
| SMILES | CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC |
| Synonyms | AP-26113 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 40 mg/mL (75.61 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (175.8 mM) | ||
| In vivo | NMP+PEG300 (10+90, v+v) | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.9 mL | 94.52 mL | 189.03 mL |
| 0.5 mM | 3.78 mL | 18.9 mL | 37.81 mL |
| 1 mM | 1.89 mL | 9.45 mL | 18.9 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
