Apatinib (YN968D1)

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VEGFR inhibitor

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Catalog No. A11407

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Apatinib 5mg A11407-5

Regular Price: $100.00

Special Price: $85.00

Apatinib 10mg A11407-10

Regular Price: $150.00

Special Price: $127.50

Apatinib 50mg A11407-50

Regular Price: $350.00

Special Price: $297.50

Apatinib 100mg A11407-100

Regular Price: $450.00

Special Price: $382.50

Apatinib (YN968D1) 10mM * 1mL in DMSO A11407-10mM-D

Regular Price: $110.00

Special Price: $93.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue.

Apatinib (YN968D1)

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Chemical Information

Catalog Num A11407
Actions Inhibitor
M. Wt 493.6
Formula C25H27N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 811803-05-1
Synonyms N/A
SMILES code CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
Chemical Name N-[4-(1-cyanocyclopentyl) phenyl-2-(4-picolyl)amino-3-Nicotinamide methanesulphonate

Biological Activity

Description
Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue.
Targets
Target Value
VEGFR2IC50: 1nM
RETIC50: 13nM
c-KitIC50: 429nM
c-SrcIC50: 530nM
PDGFRαIC50: >1μM
EGFRIC50: >10μM
HER2IC50: >10μM
FGFR1IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 22 mg/mL (44.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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