AST 487
Catalog No.: A15003
RET kinase inhibitor
AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
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Biological Activity
| Description | AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret. |
|---|
Product Information
| Catalog Num | A15003 |
|---|---|
| Formula | C26H30F3N7O2 |
| Molecular Weight | 529.56 |
| CAS Number | 630124-46-8 |
| SMILES | CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F |
| Synonyms | NVP-AST 487 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro | DMSO | 89 mg/mL (168.06 mM) | |
| Water | Insoluble | ||
| Ethanol | 29 mg/mL | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.88 mL | 94.42 mL | 188.84 mL |
| 0.5 mM | 3.78 mL | 18.88 mL | 37.77 mL |
| 1 mM | 1.89 mL | 9.44 mL | 18.88 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
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Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
