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AT101 acetic acid

pan Bcl-2 inhibitor

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Catalog No. A13578

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT101 acetic acid 10mg A13578-10
$100.00
AT101 acetic acid 25mg A13578-25
$200.00
AT101 acetic acid 50mg A13578-50
$350.00
AT101 acetic acid 100mg A13578-100
$600.00
AT101 10mM * 1mL in DMSO A13578-10mM-D
$117.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID

AT101 acetic acid

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Chemical Information

Catalog Num A13578
Actions Inhibitor
M. Wt 578.61
Formula C30H30O8.C2H4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 866541-93-7
Synonyms AT-101, AT 101
SMILES code CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C.CC(=O)O
Chemical Name R-(-)-gossypol acetic acid

Biological Activity

Description
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
Targets
Mcl-1 (Cell-free assay) Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay)
0.18 μM(Ki)0.32 μM(Ki)0.48 μM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 116 mg/mL (200.48 mM)
Water <1 mg/mL (<1 mM)
Ethanol 89 mg/mL (153.81 mM)
In vivo 0.5% CMC 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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