AZD4547 ON SALE FGFR inhibitor

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Catalog No. A11075

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZD4547 5mg A11075-5

Regular Price: $50.00

Special Price: $42.50

AZD4547 10mg A11075-10

Regular Price: $70.00

Special Price: $59.50

AZD4547 50mg A11075-50

Regular Price: $140.00

Special Price: $119.00

AZD4547 100mg A11075-100

Regular Price: $190.00

Special Price: $161.50

AZD4547 10mM * 1mL in DMSO A11075-10mM-D

Regular Price: $55.00

Special Price: $46.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

AZD4547

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Chemical Information

Catalog Num A11075
Actions Inhibitor
M. Wt 463.6
Formula C26H33N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1035270-39-3
Synonyms AZD-4547
SMILES code C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
Chemical Name N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

Biological Activity

Description
AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
Targets
Target Value
FGFR1IC50: 0.2nM
FGFR3IC50: 1.8nM
FGFR2IC50: 2.5nM
KDRIC50: 24nM
FGFR4IC50: 165nM
IGFRIC50: 581nM
AxlIC50: >2μM
CDK2IC50: >10μM
FAKIC50: >10μM
ROCK2IC50: >50μM
Akt1IC50: >100μM
ALK1IC50: >100μM
p38IC50: >100μM
PI3KαIC50: >100μM

Solubility

Solubility (25°C) * In vitro DMSO 92 mg/mL (198.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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