Cediranib (AZD2171)

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VEGFR inhibitor

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Catalog No. A10185

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cediranib 5mg A10185-5

Regular Price: $40.00

Special Price: $32.00

Cediranib 10mg A10185-10

Regular Price: $75.00

Special Price: $60.00

Cediranib 50mg A10185-50

Regular Price: $280.00

Special Price: $224.00

Cediranib 100mg A10185-100

Regular Price: $420.00

Special Price: $336.00

Cediranib (AZD2171) 10mM * 1mL in DMSO A10185-10mM-D

Regular Price: $95.00

Special Price: $76.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Cediranib (AZD2171) s a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.

Cediranib (AZD2171)

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Chemical Information

Catalog Num A10185
Actions Inhibitor
M. Wt 450.5
Formula C25H27FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 288383-20-0
Synonyms Recentin
SMILES code CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5
Chemical Name 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline

Biological Activity

Description
Cediranib (AZD2171) s a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.
Targets
Target Value
VEGFR2/KDRIC50: 0.5nM
c-KitIC50: 2nM
VEGFR3/FLT4IC50: <=3nM
VEGFR1/FLT1IC50: 5nM
PDGFRβIC50: 5nM
FGFR1IC50: 26nM
PDGFRαIC50: 36nM
CSF-1RIC50: 110nM
SrcIC50: 130nM
AblIC50: 260nM
FLT3IC50: >1μM
HER2/ErbB2IC50: >1μM
CDK2IC50: >1μM
CDK4IC50: >1μM
EGFRIC50: 1.6μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
MEKIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 90 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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