DCC-2036 (Rebastinib)

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Bcr-Abl inhibitor

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Catalog No. A11200

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
DCC-2036 5mg A11200-5

Regular Price: $140.00

Special Price: $112.00

DCC-2036 10mg A11200-10

Regular Price: $220.00

Special Price: $176.00

DCC-2036 50mg A11200-50

Regular Price: $600.00

Special Price: $480.00

DCC-2036 100mg A11200-100

Regular Price: $980.00

Special Price: $784.00

DCC-2036 10mM * 1mL in DMSO A11200-10mM-D

Regular Price: $214.00

Special Price: $171.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

DCC-2036 (Rebastinib)

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Chemical Information

Catalog Num A11200
Actions Inhibitor
M. Wt 553.59
Formula C30H28FN7O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1020172-07-9
Synonyms DCC2036
SMILES code CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5
Chemical Name N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

Biological Activity

Description

DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

Targets
Target Value
u-Abl1(native)IC50: 0.75nM
Abl1(H396P)IC50: 1.4nM
p-Abl1(native)IC50: 2nM
FLT3IC50: 2nM
p-Abl1(T315I)IC50: 4nM
KDRIC50: 4nM
u-Abl1(T315I)IC50: 5nM
Tie-2IC50: 6nM
LynIC50: 29nM
SrcIC50: 34nM
FGRIC50: 38nM
HckIC50: 40nM
PDGFRαIC50: 70nM
PDGFRβIC50: 113nM
c-KitIC50: 481nM
AuroraAIC50: >5μM
CDK2/CyclinDIC50: >5μM

Solubility

Solubility (25°C) * In vitro DMSO 111 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (28.9 mM)
In vivo 0.5% CMC/0.25% Tween 80 16 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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