Dovitinib Dilactic acid (TKI258 Dilactic acid)

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RTK inhibitor

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Catalog No. A10198

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Dovitinib Dilactic acid 10mg A10198-10

Regular Price: $60.00

Special Price: $48.00

Dovitinib Dilactic acid 25mg A10198-25

Regular Price: $128.00

Special Price: $102.40

Dovitinib Dilactic acid 50mg A10198-50

Regular Price: $208.00

Special Price: $166.40

Dovitinib Dilactic acid 100mg A10198-100

Regular Price: $380.00

Special Price: $304.00

Dovitinib Dilactic acid 10mM * 1mL in DMSO A10198-10mM-D

Regular Price: $93.00

Special Price: $74.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.

Dovitinib Dilactic acid (TKI258 Dilactic acid)

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Chemical Information

Catalog Num A10198
Actions Inhibitor
M. Wt 572.6
Formula C21H21FN6O.2C3H6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 852433-84-2
Synonyms CHIR-258, TKI258
SMILES code CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3
Chemical Name 2-Hydroxypropanoic acid compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone

Biological Activity

Description
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
Targets
Target Value
FLT3IC50: 1nM
c-KitIC50: 2nM
FGFR1IC50: 8nM
VEGFR3/FLT4IC50: 8nM
FGFR3IC50: 9nM
VEGFR1/FLT1IC50: 10nM
VEGFR2/Flk1IC50: 13nM
PDGFRβIC50: 27nM
CSF-1R/c-FmsIC50: 36nM
PDGFRαIC50: 210nM
Insulin ReceptorIC50: 2μM
EGFRIC50: 2μM
c-MetIC50: >3μM
EphA2IC50: 4μM
Tie-2IC50: 4μM
IGF-1RIC50: >10μM
HER2IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 90 mg/mL (157.18 mM)
Water 70 mg/mL (122.25 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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