Dovitinib (TKI-258)

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
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Product Name Price Stock Qty
Dovitinib 10mg
$86.00
In stock
Dovitinib 25mg
$172.00
In stock
Dovitinib 50mg
$258.00
In stock
Dovitinib 100mg
$430.00
In stock
Dovitinib (TKI-258) 10mM * 1mL in DMSO
$75.00
In stock
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Adooq Products cited in reputable paper
Adooq's Dovitinib (TKI-258) has been cited by 1 publications
  • Yunping Hu, .et al. , Cancer Lett, 2022, Oct 28;547:215867 PMID: 35985510
  • Biological Activity
    Discription Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A11411
    Formula C21H21FN6O
    Molecular Weight 392.4
    CAS Number 405169-16-6
    SMILES CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C\4/C(=C5C(=NC4=O)C=CC=C5F)N)/N3
    Synonyms CHIR-258, CHIR258, TKI258
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 28 mg/mL (71.34 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.48 mL 127.42 mL 254.84 mL
    0.5 mM 5.1 mL 25.48 mL 50.97 mL
    1 mM 2.55 mL 12.74 mL 25.48 mL
    5 mM 0.51 mL 2.55 mL 5.1 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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