E7080 (Lenvatinib)

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VEGFR Inhibitor

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Catalog No. A10340

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
E7080 5mg A10340-5

Regular Price: $50.00

Special Price: $42.50

E7080 10mg A10340-10

Regular Price: $70.00

Special Price: $59.50

E7080 50mg A10340-50

Regular Price: $150.00

Special Price: $127.50

E7080 100mg A10340-100

Regular Price: $250.00

Special Price: $212.50

E7080 (Lenvatinib) 10mM * 1mL in DMSO A10340-10mM-D

Regular Price: $55.00

Special Price: $46.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.

E7080 (Lenvatinib)

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Chemical Information

Catalog Num A10340
Actions Inhibitor
M. Wt 426.9
Formula C21H19ClN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 417716-92-8
Synonyms E-7080
SMILES code COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
Chemical Name 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamid

Biological Activity

Description
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
Targets
Target Value
VEGFR2/KDRIC50: 4.0nM
VEGFR3/FLT4IC50: 5.2nM
VEGFR1/FLT1IC50: 22nM
PDGFRβIC50: 39nM
FGFR1IC50: 46nM
PDGFRαIC50: 51nM
KitIC50: 100nM
EphB4IC50: >10μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
SrcIC50: >10μM
Akt1IC50: >10μM
CDK4/CyclinDIC50: >10μM
PLK1IC50: >10μM
FAKIC50: >10μM
PKCαIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 40 mg/mL (93.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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