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G-749

FLT3 inhibitor

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Catalog No. A14214

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
G-749 5mg A14214-5

Regular Price: $120.00

Special Price: $96.00

G-749 10mg A14214-10

Regular Price: $210.00

Special Price: $168.00

G-749 25mg A14214-25

Regular Price: $470.00

Special Price: $376.00

G-749 10mM * 1mL in DMSO A14214-10mM-D

Regular Price: $138.00

Special Price: $110.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).

G-749

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Chemical Information

Catalog Num A14214
Actions Inhibitor
M. Wt 521.41
Formula C25H25BrN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1457983-28-6
Synonyms G749
SMILES code CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(C=C4)OC5=CC=CC=C5
Chemical Name 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-pyrido[4,3-d]pyrimidin-5(6H)-one

Biological Activity

Description
G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).
Targets
Target Value
FLT3IC50: 0.4nM
FLT3(D835Y)IC50: 0.6nM
MerIC50: 1nM
AuroraBIC50: 6nM
RETIC50: 9nM
VEGFR1/FLT1IC50: 18nM
FmsIC50: 19nM
AxlIC50: 20nM
AuroraCIC50: 24nM
FGFR1IC50: 25nM
FGFR3IC50: 30nM
VEGFR2/KDRIC50: 39nM
c-KitIC50: 142nM
IGF-1RIC50: >300nM
PDGFRαIC50: >300nM
PDGFRβIC50: >300nM

Solubility

Solubility (25°C)* In vitro DMSO 24 mg/mL heating (46.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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