GNF 5837 ON SALE TRK inhibitor

0 Customer Reviews
Catalog No. A13730

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GNF 5837 10mg A13730-10

Regular Price: $100.00

Special Price: $85.00

GNF 5837 25mg A13730-25

Regular Price: $200.00

Special Price: $170.00

GNF 5837 50mg A13730-50

Regular Price: $350.00

Special Price: $297.50

GNF 5837 100mg A13730-100

Regular Price: $600.00

Special Price: $510.00

GNF 5837 10mM * 1mL in DMSO A13730-10mM-D

Regular Price: $113.00

Special Price: $96.05

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.

GNF 5837

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A13730
Actions Inhibitor
M. Wt 535.49
Formula C28H21F4N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1033769-28-6
Synonyms GNF-5837, GNF5837
SMILES code CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4
Chemical Name (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Biological Activity

Description
GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
Targets
Target Value
TrkCIC50: 7nM
TrkBIC50: 9nM
TrkAIC50: 11nM
PDGFRβIC50: 0.87μM
KitIC50: 0.91μM
JAK2IC50: 2.9μM
ALKIC50: 3.4μM
CSF-1RIC50: 4μM
FLT3IC50: 5.1μM
RETIC50: 5.3μM
MetIC50: 5.8μM
FGFR4IC50: 7μM
SrcIC50: 7.3μM
IGF-1RIC50: 7.6μM
Insulin ReceptorIC50: 8μM
AblIC50: 8.2μM
FGFR3IC50: 9.3μM

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (186.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL heating (16.8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy GNF 5837 | GNF 5837 Supplier | purchase GNF 5837 | GNF 5837 cost | GNF 5837 manufacturer | order GNF 5837 | GNF 5837 distributor | buy 1033769-28-6| 1033769-28-6 Supplier | purchase 1033769-28-6 | 1033769-28-6 cost | 1033769-28-6 manufacturer | order 1033769-28-6 | 1033769-28-6 distributor