Ki8751

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VEGFR-2 inhibitor

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Catalog No. A10502

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ki8751 5mg A10502-5

Regular Price: $50.00

Special Price: $42.50

Ki8751 10mg A10502-10

Regular Price: $75.00

Special Price: $63.75

Ki8751 50mg A10502-50

Regular Price: $300.00

Special Price: $255.00

Ki8751 100mg A10502-100

Regular Price: $500.00

Special Price: $425.00

Ki8751 10mM * 1mL in DMSO A10502-10mM-D

Regular Price: $80.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.

Ki8751

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Chemical Information

Catalog Num A10502
Actions Inhibitor
M. Wt 469.4
Formula C24H18F3N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 228559-41-9
Synonyms Ki-8751
SMILES code COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F
Chemical Name N-(2,4-Difluorophenyl)-N'-[4-[(6,7-d imethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea

Biological Activity

Description
Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.
Targets
Target Value
VEGFR2IC50: 0.9nM
c-KitIC50: 40nM
PDGFRαIC50: 67nM
FGFR2IC50: 170nM
EGFRIC50: >10μM
HGFRIC50: >10μM
Insulin ReceptorIC50: >10μM

Solubility

Solubility (25°C)* In vitro DMSO 47 mg/mL (100.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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