KRN 633

VEGFR Inhibitor

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Catalog No. A10504

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KRN 633 5mg A10504-5
$80.00
KRN 633 10mg A10504-10
$140.00
KRN 633 50mg A10504-50
$340.00
KRN 633 100mg A10504-100
$540.00
KRN 633 10mM * 1mL in DMSO A10504-10mM-D
$90.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).

KRN 633

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Chemical Information

Catalog Num A10504
Actions Inhibitor
M. Wt 416.9
Formula C20H21ClN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 286370-15-8
Synonyms KRN633, KRN-633
SMILES code CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
Chemical Name N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea

Biological Activity

Description
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).
Targets
Target Value
VEGFR3IC50: 125nM
VEGFR2IC50: 160nM
VEGFR1IC50: 170nM
PDGFRαIC50: 965nM
c-KitIC50: 4330nM
BTKIC50: 9200nM
PDGFRβIC50: 9850nM
Tie-2IC50: 9900nM

Solubility

Solubility (25°C) * In vitro DMSO 9 mg/mL (21.58 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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