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LDK-378

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ALK Inhibitor

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Catalog No. A13238

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LDK-378 5mg A13238-5
$40.00
LDK-378 10mg A13238-10
$70.00
LDK-378 50mg A13238-50
$100.00
LDK-378 10mM * 1mL in DMSO A13238-10mM-D
$60.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LDK378 is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target.

LDK-378

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Chemical Information

Catalog Num A13238
Actions Inhibitor
M. Wt 558.14
Formula C28H36ClN5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032900-25-6
Synonyms LDK378,LDK 378
SMILES code CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
Chemical Name 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Biological Activity

Description
LDK378 is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target.
Targets
Target Value
ALKIC50: 0.2nM
Insulin ReceptorIC50: 7nM
IGF-1RIC50: 8nM
STK22DIC50: 23nM
FLT3IC50: 60nM
FGFR2IC50: 0.26μM
RETIC50: 0.4μM
FGFR3IC50: 0.43μM
LCKIC50: 0.56μM
JAK2IC50: 0.61μM
AuroraAIC50: 0.66μM
LynIC50: 0.84μM
EGFRIC50: 0.9μM
FGFR4IC50: 0.95μM
PDGFRαIC50: 1.14μM
AblIC50: 1.25μM
ROCK2IC50: 1.27μM
c-KitIC50: 1.28μM
MKNK2IC50: 2.24μM
SykIC50: 3.05μM
c-MetIC50: 3.17μM
BTKIC50: 3.36μM
JAK1IC50: 3.73μM
CDK2IC50: 3.97μM
CDK4IC50: 4.72μM
ZAP70IC50: 9.7μM
AktIC50: >10μM
GSK-3αIC50: >10μM
GSK-3βIC50: >10μM
PAK2IC50: >10μM

Solubility

Solubility (25°C)* In vitro DMSO 20 mg/mL heating (35.83 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.37 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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