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NSC59984

P53 Activator

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Catalog No. A13413

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NSC59984 5mg A13413-5
$110.00
NSC59984 10mg A13413-10
$190.00
NSC59984 25mg A13413-25
$400.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.

NSC59984

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Chemical Information

Catalog Num A13413
Actions Activator
M. Wt 265.27
Formula C12H15N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 803647-40-7
Synonyms NSC 59984, NSC-59984
SMILES code CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]
Chemical Name (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one

Biological Activity

Description
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Targets
p53

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