Nutlin 3a

Catalog No.: A11501
MDM2 inhibitor
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
Grouped product items
Product Name Price Stock Qty
Nutlin 3a 5mg
$70.00
In stock
Nutlin 3a 10mg
$120.00
In stock
Nutlin 3a 25mg
$220.00
In stock
Nutlin 3a 50mg
$380.00
In stock
Nutlin 3a 10mM * 1mL in DMSO
$140.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Nutlin 3a has been cited by 3 publications
  • Sho Watanabe, .et al. , J Crohns Colitis, 2021, Feb 17 PMID: 33596306
  • Shun Zhang, .et al. , BPB Reports, 2019, 2, 130-133
  • Momoko Ishimine, .et al. , Dis Markers, 2018, 2018: 5280736 PMID: 29651325
  • Biological Activity
    Discription Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
    Targets
    Target Value
    Product Information
    Catalog Num A11501
    Formula C30H30Cl2N4O4
    Molecular Weight 581.49
    CAS Number 675576-98-4
    SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
    Synonyms Nutlin-3a, (-)-Nutlin-3
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 98 mg/mL (168.53 mM)
    Water Insoluble
    Ethanol 98 mg/mL
    In vivo 5% DMSO+55% PEG 300+ddH2O 7 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.2 mL 85.99 mL 171.97 mL
    0.5 mM 3.44 mL 17.2 mL 34.39 mL
    1 mM 1.72 mL 8.6 mL 17.2 mL
    5 mM 0.34 mL 1.72 mL 3.44 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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