Nutlin 3a

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MDM2 inhibitor

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Catalog No. A11501

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Nutlin 3a 5mg A11501-5

Regular Price: $70.00

Special Price: $56.00

Nutlin 3a 10mg A11501-10

Regular Price: $120.00

Special Price: $96.00

Nutlin 3a 25mg A11501-25

Regular Price: $220.00

Special Price: $176.00

Nutlin 3a 50mg A11501-50

Regular Price: $380.00

Special Price: $304.00

Nutlin 3a 10mM * 1mL in DMSO A11501-10mM-D

Regular Price: $140.00

Special Price: $112.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.

Nutlin 3a

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Chemical Information

Catalog Num A11501
Actions Inhibitor
M. Wt 581.49
Formula C30H30Cl2N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 675576-98-4
Synonyms Nutlin-3a, (-)-Nutlin-3
SMILES code CC(C)OC1=C(C=CC(=C1)OC)C2=N[[email protected]]([[email protected]](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Chemical Name 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one

Biological Activity

Description
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
Targets
p53/MDM2 interaction (Cell-free assay)
90 nM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (171.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (171.97 mM)
In vivo 2% DMSO/1% hydroxyethyl cellulose/0.2% Tween 80 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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