PD173074

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FGFR Inhibitor

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Catalog No. A10703

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD173074 5mg A10703-5

Regular Price: $30.00

Special Price: $24.00

PD173074 10mg A10703-10

Regular Price: $50.00

Special Price: $40.00

PD173074 50mg A10703-50

Regular Price: $140.00

Special Price: $112.00

PD173074 100mg A10703-100

Regular Price: $220.00

Special Price: $176.00

PD173074 10mM * 1mL in DMSO A10703-10mM-D

Regular Price: $50.00

Special Price: $40.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

PD173074

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Chemical Information

Catalog Num A10703
Actions Inhibitor
M. Wt 523.7
Formula C28H41N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 219580-11-7
Synonyms PD-173074
SMILES code CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
Chemical Name N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

Biological Activity

Description
PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
Targets
Target Value
FGFR1IC50: ~25nM
VEGFR2IC50: 100nM-200nM
c-SrcIC50: 19.8μM
EGFRIC50: >50μM
Insulin ReceptorIC50: >50μM
MEKIC50: >50μM
PKCIC50: >50μM

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (190.95 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (190.95 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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