PD173955

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Bcr-Abl inhibitor

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Catalog No. A13120

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD173955 5mg A13120-5

Regular Price: $120.00

Special Price: $102.00

PD173955 10mg A13120-10

Regular Price: $200.00

Special Price: $170.00

PD173955 25mg A13120-25

Regular Price: $350.00

Special Price: $297.50

PD173955 50mg A13120-50

Regular Price: $600.00

Special Price: $510.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.

PD173955

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Chemical Information

Catalog Num A13120
Actions Inhibitor
M. Wt 443.35
Formula C21H16Cl2N4OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 260415-63-2
Synonyms PD 173955; PD-173955
SMILES code CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
Chemical Name 6-(2,6-Dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

Biological Activity

Description
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.
Targets
Bcr-Abl Src
1 nM-2 nM22 nM

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