PF-06463922

ALK inhibitor

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Catalog No. A14207

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-06463922 5mg A14207-5
$60.00
PF-06463922 10mg A14207-10
$90.00
PF-06463922 25mg A14207-25
$150.00
PF-06463922 10mM * 1mL in DMSO A14207-10mM-D
$66.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

PF-06463922

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Chemical Information

Catalog Num A14207
Actions Inhibitor
M. Wt 406.41
Formula C21H19FN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1454846-35-5
Synonyms PF 06463922, PF06463922
SMILES code C[[email protected]@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
Chemical Name (10R)-7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile

Biological Activity

Description
PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
Targets
Target Value
ROS1ki: <0.02nM
ROS1ki: <0.02nM
ALKki: <0.07nM
ALK(L1196M)ki: 0.07nM
LTK(TYK1)IC50: 2.7nM
FERIC50: 3.3nM
FES(FPS)IC50: 6nM
PTK2B(FAK2)IC50: 14nM
TNK2(ACK)IC50: 17nM
PTK2(FAK)IC50: 17nM
NTRK2(TRKB)IC50: 23nM
NTRK2(TRKB)ki: 23nM
NTRK1(TRKA)IC50: 24nM
NTRK3(TRKC)IC50: 46nM
FRK(PTK5)IC50: 53nM
EGFR(ErbB1)T790ML858RIC50: 245nM
IGF1RIC50: 296nM
STK22B(TSSK2)IC50: 302nM
EGFR(ErbB1)T790MIC50: 319nM
DCAMKL2(DCK2)IC50: 370nM
EPHA1IC50: 375nM
JAK2IC50: 529nM

Solubility

Solubility (25°C)* In vitro DMSO 81 mg/mL (199.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL heating (199.3 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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