PF-562271

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FAK inhibitor

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Catalog No. A11192

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-562271 5mg A11192-5
$120.00
PF-562271 10mg A11192-10
$180.00
PF-562271 50mg A11192-50
$450.00
PF-562271 100mg A11192-100
$800.00
PF-562271 10mM * 1mL in DMSO A11192-10mM-D
$181.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.

PF-562271

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Chemical Information

Catalog Num A11192
Actions Inhibitor
M. Wt 507.49
Formula C21H20F3N7O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 717907-75-0
Synonyms PF562271
SMILES code CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
Chemical Name N-methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide

Biological Activity

Description
PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.
Targets
Target Value
FAKIC50: 1.5nM
PYK2IC50: 13nM
CDK2/CyclinEIC50: 30nM
CDK3/CyclinEIC50: 47nM
CDK1/CyclinBIC50: 58nM
CDK7/CyclinH/MAT1IC50: 97nM
FLT3IC50: 97nM
GSK-3αIC50: 101nM
CDK5/p35IC50: 120nM
GSK-3βIC50: 133nM
AuroraAIC50: 145nM
CDK2/CyclinAIC50: 227nM
YESIC50: 294nM
MAPK1IC50: 340nM
FynIC50: 377nM
LCKIC50: 408nM
IGF-1RIC50: >500nM
PKAIC50: 620nM
c-SrcIC50: 797nM
CDK4IC50: >1μM
CDK6/CyclinD2IC50: >1μM
Chk1IC50: >1μM
Chk2IC50: >1μM
EGFRIC50: >1μM
EphB2IC50: >1μM
FGFR3IC50: >1μM
AblIC50: >1μM
FmsIC50: >1μM
IKKαIC50: >1μM
IKKβIC50: >1μM
JNK1α1IC50: >1μM
MEK1IC50: >1μM
p70S6KIC50: >1μM
PKBαIC50: >1μM
PKBβIC50: >1μM
PKBγIC50: >1μM
PKCαIC50: >1μM
PKCβ2IC50: >1μM
PKCδIC50: >1μM
TrkBIC50: >2.5μM
PDGFRβIC50: >3μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL heating (197.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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