PP2

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Src Inhibitor

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Catalog No. A12723

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PP2 10mg A12723-10

Regular Price: $100.00

Special Price: $80.00

PP2 25mg A12723-25

Regular Price: $220.00

Special Price: $176.00

PP2 50mg A12723-50

Regular Price: $300.00

Special Price: $240.00

PP2 100mg A12723-100

Regular Price: $500.00

Special Price: $400.00

PP2 10mM * 1mL in DMSO A12723-10mM-D

Regular Price: $90.00

Special Price: $72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).

PP2

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Chemical Information

Catalog Num A12723
Actions Inhibitor
M. Wt 310.78
Formula C15H16ClN5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 172889-27-9
Synonyms PP-2, PP 2
SMILES code CC(C)(C)N1C2=C(C(=N1)C3=CC=C(C=C3)Cl)C(=NC=N2)N
Chemical Name 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3?,4-d]pyrimidin-4-amine

Biological Activity

Description
PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
Targets
LCK (Cell-free assay) Fyn (Cell-free assay) EGFR (Cell-free assay) JAK2 (Cell-free assay) ZAP70 (Cell-free assay)
4 nM5 nM480 nM>50 μM>100 μM

Solubility

Solubility (25°C) * In vitro DMSO 60 mg/mL (198.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.62 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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