PRT062607 HCL

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Syk Inhibitor

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Catalog No. A12731

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PRT062607 HCL 5mg A12731-5
$90.00
PRT062607 HCL 10mg A12731-10
$160.00
PRT062607 HCL 25mg A12731-25
$300.00
PRT062607 HCL 50mg A12731-50
$480.00
PRT062607 HCL 10mM * 1mL in DMSO A12731-10mM-D
$125.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

PRT062607 HCL

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Chemical Information

Catalog Num A12731
Actions Inhibitor
M. Wt 429.91
Formula C19H24ClN9O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1370261-97-4
Synonyms P505-15, PRT2607, PRT-2607, PRT 2607, PRT-062607, PRT 062607, P505-15, BIIB057
SMILES code C1CC[[email protected]]([[email protected]](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl
Chemical Name 4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride

Biological Activity

Description
PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
Targets
Target Value
SykIC50: 1nM
FGRIC50: 81nM
MLK1IC50: 88nM
YESIC50: 123nM
FLT3IC50: 139nM
PAK5IC50: 166nM
LynIC50: 192nM
c-SrcIC50: 244nM
LCKIC50: 249nM

Solubility

Solubility (25°C) * In vitro DMSO 86 mg/mL (200.04 mM)
Water 86 mg/mL (200.04 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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