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R428

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Axl Inhibitor

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Catalog No. A13741

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
R428 2mg A13741-2

Regular Price: $80.00

Special Price: $64.00

R428 5mg A13741-5

Regular Price: $150.00

Special Price: $120.00

R428 10mg A13741-10

Regular Price: $250.00

Special Price: $200.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.

R428

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Chemical Information

Catalog Num A13741
Actions Inhibitor
M. Wt 506.64
Formula C30H34N8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1037624-75-1
Synonyms BGB324, BGB 324, BGB-324, R-428
SMILES code C1CCN(C1)[[email protected]]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
Chemical Name 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine

Biological Activity

Description
R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.
Targets
Axl
14 nM

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