RG7112

Catalog No.: A11523
selective p53-MDM2 inhibitor
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
Grouped product items
Product Name Price Stock Qty
RG7112 5mg
$120.00
In stock
RG7112 10mg
$210.00
In stock
RG7112 50mg
$640.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
Product Information
Catalog Num A11523
Formula C38H48Cl2N4O4S
Molecular Weight 727.78
CAS Number 939981-39-2
SMILES CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
Synonyms RG-7112, RG 7112, RO5045337
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 97 mg/mL (133.55 mM)
Water Insoluble
Ethanol 97 mg/mL (133.55 mM)
In vivo 1% CMC Na 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.74 mL 68.7 mL 137.4 mL
0.5 mM 2.75 mL 13.74 mL 27.48 mL
1 mM 1.37 mL 6.87 mL 13.74 mL
5 mM 0.27 mL 1.37 mL 2.75 mL
Useful Calculator

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