Saracatinib (AZD0530)

Anniversary Sale 20% OFF

Src/Abl inhibitor

0 Customer Reviews
Catalog No. A10108

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Saracatinib 10mg A10108-10

Regular Price: $60.00

Special Price: $48.00

Saracatinib 25mg A10108-25

Regular Price: $90.00

Special Price: $72.00

Saracatinib 100mg A10108-100

Regular Price: $220.00

Special Price: $176.00

Saracatinib 200mg A10108-200

Regular Price: $390.00

Special Price: $312.00

Saracatinib (AZD0530) 10mM * 1mL in DMSO A10108-10mM-D

Regular Price: $92.00

Special Price: $73.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.

Saracatinib (AZD0530)

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A10108
Actions Inhibitor
M. Wt 542.0
Formula C27H32ClN5O5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 379231-04-6
Synonyms AZD-0530
SMILES code CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6
Chemical Name N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

Biological Activity

Description
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
Targets
Target Value
c-SrcIC50: 2.7nM
LCKIC50: <4nM
c-YESIC50: 4nM
EGFR(L861Q)IC50: 4nM
LynIC50: 5nM
EGFR(L858R)IC50: 5nM
FynIC50: 10nM
FGRIC50: 10nM
BLKIC50: 11nM
v-AblIC50: 30nM
EGFRIC50: 66nM
c-KitIC50: 200nM
EphA2IC50: 236nM
CSKIC50: >1μM
PDGFRβIC50: >5μM
PDGFRαIC50: 10μM
CDK2IC50: 10μM
VEGFR3/FLT4IC50: >10μM
FGFR1IC50: >10μM
MEKIC50: 14μM
VEGFR2/KDRIC50: 21μM
VEGFR1/FLT1IC50: >100μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (184.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (184.49 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy Saracatinib (AZD0530) | Saracatinib (AZD0530) Supplier | purchase Saracatinib (AZD0530) | Saracatinib (AZD0530) cost | Saracatinib (AZD0530) manufacturer | order Saracatinib (AZD0530) | Saracatinib (AZD0530) distributor | buy 379231-04-6| 379231-04-6 Supplier | purchase 379231-04-6 | 379231-04-6 cost | 379231-04-6 manufacturer | order 379231-04-6 | 379231-04-6 distributor